252845-37-7
252845-37-7 structure
- Name: Veldoreotide
- Chemical Name: Veldoreotide
- CAS Number: 252845-37-7
- Molecular Formula: C60H74N12O10
- Molecular Weight: 1123.30
- Catalog: Signaling Pathways GPCR/G Protein Somatostatin Receptor
- Create Date: 2022-12-02 17:28:07
- Modify Date: 2024-01-10 18:02:17
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Veldoreotide (DG3173) a somatostatin analogue, that can bind to and activate the somatostatin receptors (SSTR) 2, 4, and 5. Veldoreotide inhibits growth hormone (GH) secretion in adenomas compared with Octreotide (HY-P0036). Veldoreotide has the potential to be used as pain modulating agent[1]
| Name | Veldoreotide |
|---|
| Description | Veldoreotide (DG3173) a somatostatin analogue, that can bind to and activate the somatostatin receptors (SSTR) 2, 4, and 5. Veldoreotide inhibits growth hormone (GH) secretion in adenomas compared with Octreotide (HY-P0036). Veldoreotide has the potential to be used as pain modulating agent[1] |
|---|---|
| Related Catalog | |
| Target |
SSTR2:37.6 ± 4.5 nM (EC50) SSTR3:31.3 ± 14. nM (EC50) SSTR4:10.5 ± 3.4 nM (EC50) |
| In Vitro | Veldoreotide stimulates the SST2, SST4, and SST5 receptors with high potency and efficacy in the HEK293 cells, co-expressing these receptors with the GIRK2 channels; EC50s of 37.6 ± 4.5 nM, 31.3 ± 14.4 nM and 10.5 ± 3.4 nM for GIRK2-SST2, GIRK2-SST4 and GIRK2-SST5, respectively[1]. Veldoreotide (10 μM; 24 h) inhibits SST4-expressing BON-1 cells[1]. Veldoreotide (DG3173) (100 nM or 1 μM; 6 h) inhibits GH secreation in adenomas with an IC50 of 0.49 nM[2]. Cell Proliferation Assay[1] Cell Line: SST4-expressing BON-1 cells Concentration: 10 μM Incubation Time: 24 h Result: Inhibited SST4-expressing BON-1 cells, while did not significantly inhibited wild type BON-1 cells. |
| Molecular Formula | C60H74N12O10 |
|---|---|
| Molecular Weight | 1123.30 |