2304448-00-6

2304448-00-6 structure

Name: Antibacterial agent 124
Chemical Name: Antibacterial agent 124
CAS Number: 2304448-00-6
Molecular Formula: C₁₆H₁₇ClFN₃O₂
Molecular Weight: 337.78
Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
Create Date: 2023-02-27 18:13:08
Modify Date: 2024-04-06 15:10:02
Antibacterial agent 124 (Compound 3) is a potent bacterial prolyl-tRNA synthetase (ProRS) inhibitor with an IC50 of 0.18 μM against Staphylococcus aureus ProRS (SaProRS)[1].

Name	Antibacterial agent 124

Description	Antibacterial agent 124 (Compound 3) is a potent bacterial prolyl-tRNA synthetase (ProRS) inhibitor with an IC50 of 0.18 μM against Staphylococcus aureus ProRS (SaProRS)[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
Target	IC50: 0.18 μM (SaProRS)[1] Kd: 30.3 nM (SaProRS)[1]
In Vitro	Antibacterial agent 124 (Compound 3) shows antibacterial activity with MICs of 1, 1, 4, 1, 1, 2 and 4 μg/mL against E. coli (ATCC25922), S. flexneri (CMCC51572), S. typhi (CMCC50094), MRSA252, MRSA R3708, S. aureus ATCC29213, S. aureus ATCC25923, respectively. And the CC50 to HepG2 is 4.32 μM[1].
References	[1]. Cheng B, et al. Structure-Guided Design of Halofuginone Derivatives as ATP-Aided Inhibitors Against Bacterial Prolyl-tRNA Synthetase. J Med Chem. 2022 Nov 17.

Molecular Formula	C₁₆H₁₇ClFN₃O₂
Molecular Weight	337.78