1826819-58-2
1826819-58-2 structure
- Name: Azintuxizumab vedotin
- Chemical Name: Azintuxizumab vedotin
- CAS Number: 1826819-58-2
- Molecular Formula:
- Molecular Weight:
- Catalog: Research Areas Cancer
- Create Date: 2023-01-26 10:34:11
- Modify Date: 2024-04-07 17:32:24
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Azintuxizumab vedotin (ABBV-838) is an antibody–drug conjugate (ADC) targeting a unique epitope of CD2 subset 1, a cell-surface glycoprotein expressed on multiple myeloma cells[1].
| Name | Azintuxizumab vedotin |
|---|
| Description | Azintuxizumab vedotin (ABBV-838) is an antibody–drug conjugate (ADC) targeting a unique epitope of CD2 subset 1, a cell-surface glycoprotein expressed on multiple myeloma cells[1]. |
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| Related Catalog | |
| Target |
CD2 subset 1[1] |
| In Vitro | Azintuxizumab vedotin (ABBV-838) 是一种 ADC，由人源化重组免疫球蛋白 G1κ 组成，针对 CD2 subset 1 (CS1，也称为 SLAMF7) 的独特表位，通过缬氨酸-瓜氨酸连接子与细胞毒性单甲基 auristatin E (MMAE) 结合[1]。 Azintuxizumab vedotin 对表达 CS1 的癌细胞显示出强大的细胞毒活性[1]。 |
| In Vivo | Azintuxizumab vedotin (ABBV-838) 在使用人骨髓瘤异种移植的小鼠模型中显示单药抗肿瘤活性[1]。 |
| References |
| No Any Chemical & Physical Properties |