1453028-33-5
1453028-33-5 structure
- Name: DRP1i27
- Chemical Name: DRP1i27
- CAS Number: 1453028-33-5
- Molecular Formula: C20H26N6O
- Molecular Weight: 366.46
- Catalog: Signaling Pathways Cytoskeleton Dynamin
- Create Date: 2023-01-11 11:27:43
- Modify Date: 2024-04-05 18:34:30
-
DRP1i27 is a potent inhibitor of human Drp1 (dynamin-related protein 1). DRP1i27 binds to the GTPase site of Drp1, with hydrogen bonds to Gln34 and Asp218. DRP1i27 targets Drp1-mediated mitochondrial fission in cell line models and protects against simulated ischemia-reperfusion injury[1].
| Name | DRP1i27 |
|---|
| Description | DRP1i27 is a potent inhibitor of human Drp1 (dynamin-related protein 1). DRP1i27 binds to the GTPase site of Drp1, with hydrogen bonds to Gln34 and Asp218. DRP1i27 targets Drp1-mediated mitochondrial fission in cell line models and protects against simulated ischemia-reperfusion injury[1]. |
|---|---|
| Related Catalog | |
| In Vitro | DRP1i27 (0-50 µM) 直接结合并抑制人 Drp1 的 GTPase 活性[1]。 DRP1i27 (0-50 µM) 能够以 Drp1 依赖性方式增加人和小鼠成纤维细胞中线粒体的细胞网络[1]。 DRP1i27 在 SPR 分析中的结合亲和力为 286 µM，在 MST 分析中的 KD 值为 190 µM[1]。 |
| References |
[1]. Rosdah AA, et al. A novel small molecule inhibitor of human Drp1. Sci Rep. 2022 Dec 13;12(1):21531. |
| Molecular Formula | C20H26N6O |
|---|---|
| Molecular Weight | 366.46 |