2798007-90-4

2798007-90-4 structure

Name: Ezetimibe phenoxy glucuronide-d4-1
Chemical Name: Ezetimibe phenoxy glucuronide-d4-1
CAS Number: 2798007-90-4
Molecular Formula: C₃₀H₂₅D₄F₂NO₉
Molecular Weight: 589.57
Catalog: Research Areas Others
Create Date: 2023-01-11 19:21:51
Modify Date: 2024-04-03 17:31:12
Ezetimibe phenoxy glucuronide-d4-1 is the deuterium labeled Ezetimibe phenoxy glucuronide. Ezetimibe phenoxy glucuronide (Ezetimibe glucuronide) is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity[1]. Ezetimibe is a potent cholesterol absorption inhibitor[2][3].

Name	Ezetimibe phenoxy glucuronide-d4-1

Description	Ezetimibe phenoxy glucuronide-d4-1 is the deuterium labeled Ezetimibe phenoxy glucuronide. Ezetimibe phenoxy glucuronide (Ezetimibe glucuronide) is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity[1]. Ezetimibe is a potent cholesterol absorption inhibitor[2][3].
Related Catalog	Research Areas >> Others
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[3].
References	[1]. Stolk MF, et al. Severe hepatic side effects of ezetimibe. Clin Gastroenterol Hepatol. 2006 Jul;4(7):908-11. [2]. Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532. [3]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.

Molecular Formula	C₃₀H₂₅D₄F₂NO₉
Molecular Weight	589.57