725735-28-4
725735-28-4 structure
- Name: Intetumumab
- Chemical Name: Intetumumab
- CAS Number: 725735-28-4
- Molecular Formula:
- Molecular Weight: 145.6 (kDa)
- Catalog: Signaling Pathways JAK/STAT Signaling EGFR
- Create Date: 2023-01-14 18:51:49
- Modify Date: 2024-04-08 18:06:24
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Intetumumab (CNTO 95) is a potent anti-EGFR monoclonal antibody that is glycoengineered for enhanced antibody-dependent cellular cytotoxicity (ADCC). Intetumumab can be used in research of cancer[1][2].
| Name | Intetumumab |
|---|
| Description | Intetumumab (CNTO 95) is a potent anti-EGFR monoclonal antibody that is glycoengineered for enhanced antibody-dependent cellular cytotoxicity (ADCC). Intetumumab can be used in research of cancer[1][2]. |
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| Related Catalog | |
| In Vitro | Intetumumab (CNTO 95; 0-5 μg/mL; 20 分钟; USPC-ARK-3 细胞) 抑制整合素介导的 USPC 细胞粘附于玻璃连素底物，并抑制血清诱导的 USPC 细胞迁移[1]。 |
| In Vivo | Intetumumab (CNTO 95; 10 mg/kg; i.p.; 雄性裸大鼠) 抑制肿瘤生长，抑制 A549 肿瘤的自发肺转移，减少发生肺转移的大鼠数量和每个肺的转移病灶数量[2]。 Animal Model: Male nude rats with lung metastasis models (5-6 weeks old and 150-200 g)[2] Dosage: 10 mg/kg Administration: Intraperitoneal injection; once a week for 60 days Result: Had the total tumor response rates (CR and PR) was 33% in A549 tumor model. Developed lung metastases only 4 of 9 rats. |
| References |
| Molecular Weight | 145.6 (kDa) |
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