149270-28-0
149270-28-0 structure
- Name: [Lys5,MeLeu9,Nle10]Neurokinin A(4-10)
- Chemical Name: [Lys5,MeLeu9,Nle10]Neurokinin A(4-10)
- CAS Number: 149270-28-0
- Molecular Formula: C39H64N8O10
- Molecular Weight: 804.97
- Catalog: Signaling Pathways GPCR/G Protein Neurokinin Receptor
- Create Date: 2023-02-04 18:39:42
- Modify Date: 2024-01-12 17:18:52
-
[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (LMN-NKA), an analogue of Neurokinin A, is a selective and potent NK2R agonist. [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) has prokinetic activity. [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) can be used to study the roles of the NK-2 receptor in smooth muscle contraction in numerous tissues[1][2][3].
| Name | [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) |
|---|
| Description | [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (LMN-NKA), an analogue of Neurokinin A, is a selective and potent NK2R agonist. [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) has prokinetic activity. [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) can be used to study the roles of the NK-2 receptor in smooth muscle contraction in numerous tissues[1][2][3]. |
|---|---|
| Related Catalog | |
| Target |
NK2 |
| In Vivo | [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (30-100 μg/kg，皮下注射) 增加了小型猪的膀胱和结肠直肠压力峰值[1]。 [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (0.3 μg/kg 静脉注射或 100 μg/kg 鼻腔吸入) 也会增加膀胱和结肠直肠压力[1]。 [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (10-100 μg/kg，静脉注射，每天四次，连续六天) 在有意识的狗中引起排尿和排便、呕吐和低血压[2]. Animal Model: Anesthetized minipigs[1] Dosage: 30-100 μg/kg Administration: Subcutaneous injection (s.c.) Result: Showed significant, non-linear, dose-dependent increase in peak bladder and colorectal pressures, and was blocked by GR 159897 (HY-107691)(1 mg/kg i.v., 15 min prior to LMN-NKA). Animal Model: Conscious dogs[2] Dosage: 10-100 μg/kg Administration: Intravenous injection (i.v.), four times daily for six consecutive days. Result: Elicited NK2 receptor-mediated micturition defecation and NK1 receptor-mediated emesis and hypotension. |
| References |
[3]. Sara Good, et al. [Lys5, MeLeu9, Nle10]NKA-4-10. Reference Module in Biomedical Sciences. 2019. |
| Molecular Formula | C39H64N8O10 |
|---|---|
| Molecular Weight | 804.97 |