2249935-19-9
2249935-19-9 structure
- Name: Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine
- Chemical Name: Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine
- CAS Number: 2249935-19-9
- Molecular Formula: C51H65N17O19P2S2.xC6H15N
- Molecular Weight:
- Catalog: Signaling Pathways Immunology/Inflammation STING
- Create Date: 2023-01-19 00:28:11
- Modify Date: 2025-08-25 22:09:23
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Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine is an immune stimulator antibody conjugate (ISAC) comprising an anti-human epidermal growth factor receptor 2 (HER2) antibody, a STING agonist (ADU-S100) and a linker. Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine can be uesd for cancer research (WO2018200812A1; example 5)[1].
| Name | Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine |
|---|
| Description | Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine is an immune stimulator antibody conjugate (ISAC) comprising an anti-human epidermal growth factor receptor 2 (HER2) antibody, a STING agonist (ADU-S100) and a linker. Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine can be uesd for cancer research (WO2018200812A1; example 5)[1]. |
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| Related Catalog | |
| Target |
HER2 |
| In Vitro | STING（干扰素基因刺激物）是一种促进先天免疫信号传导的内质网衔接子。据报道，STING 包含四个假定的跨膜区域，主要位于内质网中，能够激活 NF-kB、STAT6 和 IRF3 转录途径以诱导 I 型干扰素 (例如 IFN-α 和 IFN-β) 的表达 并在表达后发挥有效的抗病毒状态。相反，STING 的缺失使小鼠胚胎成纤维细胞极易受到负链病毒感染，包括水疱性口炎病毒[1]。 |
| References |
[1]. Thomas W. Dubensky Jr., et al. Antibody conjugates comprising sting agonist. WO2018200812A1. |
| Molecular Formula | C51H65N17O19P2S2.xC6H15N |
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