634592-23-7

634592-23-7 structure

634592-23-7 structure

Name: Woodtide
Chemical Name: Woodtide
CAS Number: 634592-23-7
Molecular Formula: C₆₈H₁₂₂N₂₀O₂₁S
Molecular Weight: 1587.88
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK DYRK
Create Date: 2023-01-18 22:11:09
Modify Date: 2024-01-11 13:53:24
Woodtide is a substrate for the DYRK (DYRK) family of kinases whose sequence is based on that around the DYRK phosphorylation site in FKHR[1][2].

Name	Woodtide

Description	Woodtide is a substrate for the DYRK (DYRK) family of kinases whose sequence is based on that around the DYRK phosphorylation site in FKHR[1][2].
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> DYRK Research Areas >> Neurological Disease
In Vitro	Immunoprecipitated FLAG-dDYRK2 or FLAG-MNB is assayed using 50 μM Woodtide or 50 μM activation-loop peptide with two additional lysines attached to the N terminus to allow it to bind to P81 paper (KKSSCYVDRKIYTYIQSRFY for dDYRK2 or KKSSCQLGQRIYHYIQSRFY for MNB). Both kinases efficiently phosphorylated the synthetic exogenous substrate peptide Woodtide, but neither dDYRK2 nor MNB phosphorylated their activation-loop peptide[1].
References	[1]. Pamela A Lochhead, et al. Activation-loop autophosphorylation is mediated by a novel transitional intermediate form of DYRKs. Cell. 2005 Jun 17;121(6):925-36. [2]. Linda E Campbell, et al. Differing substrate specificities of members of the DYRK family of arginine-directed protein kinases. FEBS Lett. 2002 Jan 2;510(1-2):31-6.

Molecular Formula	C₆₈H₁₂₂N₂₀O₂₁S
Molecular Weight	1587.88