Chemical Name: Urea crosslinker – C₄-arm, NHS ester (DSBU, BuUrBU)
CAS Number: 1240387-33-0
Molecular Formula: C17H22N4O9
Molecular Weight: 426.38
Create Date: 2023-03-11 17:51:17
Modify Date: 2024-01-05 19:36:27
Description The ureido-4,4´-dibutyric acid bis(hydroxysuccinimide) ester, also known as DSBU or BuUrBU, is the longest version of MS-cleavable urea-based lysine-lysine reactive homobifunctional cross-linkers, featuring a C4-arm. At neutral or slightly basic pH, it irreversibly crosslinks the neighbouring lysine groups. The presence of the symmetrical urea moiety which is prone to collision-induced dissociation allows for the unambiguous distinguishing of crosslinks in tandem CID-MS experiments.