1818868-23-3

1818868-23-3 structure

Name: HIV-1 inhibitor-52
Chemical Name: HIV-1 inhibitor-52
CAS Number: 1818868-23-3
Molecular Formula: C₄₆H₇₂FNO₅S
Molecular Weight: 770.13
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2023-01-27 18:06:43
Modify Date: 2024-01-16 12:00:01
HIV-1 inhibitor-52 is a potent broad-spectrum HIV-1 activity inhibitor with EC50s of 1.6 nM-6.4 nM for WT HIV-1, HIV-1 V370A, HIV-1 ΔV370, HIV-1 V362I/V370A, HIV-1 T332S/V362I/prR41G, HIV-1 A326T/V362I/V370A, HIV-1 R361K/V362I/L363M[1].

Name	HIV-1 inhibitor-52

Description	HIV-1 inhibitor-52 is a potent broad-spectrum HIV-1 activity inhibitor with EC50s of 1.6 nM-6.4 nM for WT HIV-1, HIV-1 V370A, HIV-1 ΔV370, HIV-1 V362I/V370A, HIV-1 T332S/V362I/prR41G, HIV-1 A326T/V362I/V370A, HIV-1 R361K/V362I/L363M[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
Target	HIV-1 (WT):1.6 nM (EC50) HIV-1 V370A:3.0 nM (EC50) HIV-1 ΔV370:5.1 nM (EC50) HIV-1 V362I/V370A:2.0 nM (EC50) HIV-1 T332S/V362I/prR41G:6.4 nM (EC50) HIV-1 A326T/V362I/V370A:4.3 nM (EC50) HIV-1 R361K/V362I/L363M:4.5 nM (EC50)
In Vivo	HIV-1 inhibitor-52 (化合物 26; 1 mg/kg; 静脉给药) 在大鼠的 T1/2 为 4.2 小时，CL 为 3.5 mL/min·kg，Vss 为 0.8 L/kg[1]。 HIV-1 inhibitor-52 (5 mg/kg; 灌胃) 对大鼠的 Cmax 为 0.83 μM，AUC 为 8.11 μM·h[1]。 Animal Model: Male sprague-dawley rats[1] Dosage: 1 mg/kg Administration: IV Result: Had a T1/2 of 4.2 hours, a CL of 3.5 mL/min•kg, and a Vss of 0.8 L/kg for rats.
References	[1]. Richard A Hartz, et al. Synthesis, Structure-Activity Relationships, and In Vivo Evaluation of Novel C-17 Amine Derivatives Based on GSK3640254 as HIV-1 Maturation Inhibitors with Broad Spectrum Activity. J Med Chem. 2022 Dec 8;65(23):15935-15966.

Molecular Formula	C₄₆H₇₂FNO₅S
Molecular Weight	770.13