1627900-92-8

1627900-92-8 structure
1627900-92-8 structure

Name P2X7 receptor antagonist-3
Description P2X7 receptor antagonist-3 is a potent P2X7 receptor antagonist with P2X7R IC50 values of 4.2 nM in humans and 6.8 nM in rats[1].
Related Catalog
Target

hP2X7R:4.2 nM (IC50)

rP2X7R:6.8 nM (IC50)

References

[1]. Brad M Savall, et al. Synthesis, SAR, and Pharmacological Characterization of Brain Penetrant P2X7 Receptor Antagonists. ACS Med Chem Lett. 2015 Apr 24;6(6):671-6.  

Molecular Formula C17H12ClF3N6O
Molecular Weight 408.76