2412056-28-9
2412056-28-9 structure
- Name: Thalidomide-5-NH-CH2-COO(t-Bu)
- Chemical Name: Thalidomide-5-NH-CH2-COO(t-Bu)
- CAS Number: 2412056-28-9
- Molecular Formula: C19H21N3O6
- Molecular Weight: 387.39
- Catalog: Signaling Pathways PROTAC Ligand for E3 Ligase
- Create Date: 2023-02-19 17:55:52
- Modify Date: 2024-03-04 19:27:34
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Thalidomide-5-NH-CH2-COO(t-Bu) is a t-Bu modified Thalidomide (HY-14658), which acts as a Cereblon ligand to recruit CRBN protein. The t-Bu protecting group at the end of Thalidomide-5-NH-CH2-COO(t-Bu) can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-5-NH-CH2-COO(t-Bu) is a key intermediate in the synthesis of CRBN-based PROTAC molecules.
| Name | Thalidomide-5-NH-CH2-COO(t-Bu) |
|---|---|
| Synonyms | Glycine, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-, 1,1-dimethylethyl ester |
| Description | Thalidomide-5-NH-CH2-COO(t-Bu) is a t-Bu modified Thalidomide (HY-14658), which acts as a Cereblon ligand to recruit CRBN protein. The t-Bu protecting group at the end of Thalidomide-5-NH-CH2-COO(t-Bu) can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-5-NH-CH2-COO(t-Bu) is a key intermediate in the synthesis of CRBN-based PROTAC molecules. |
|---|---|
| Related Catalog |
| Molecular Formula | C19H21N3O6 |
|---|---|
| Molecular Weight | 387.39 |