2101829-58-5
2101829-58-5 structure
- Name: Glenzocimab
- Chemical Name: Glenzocimab
- CAS Number: 2101829-58-5
- Molecular Formula:
- Molecular Weight:
- Catalog: Research Areas Cardiovascular Disease
- Create Date: 2023-05-03 15:23:55
- Modify Date: 2024-01-11 12:03:27
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Glenzocimab (ACT017) is a Fab fragment of humanized anti-GPVI monoclonal antibody. Glenzocimab inhibits collagen-induced platelet aggregation. Glenzocimab has the potential for the research of acute ischemic stroke[1][2].
| Name | Glenzocimab |
|---|
| Description | Glenzocimab (ACT017) is a Fab fragment of humanized anti-GPVI monoclonal antibody. Glenzocimab inhibits collagen-induced platelet aggregation. Glenzocimab has the potential for the research of acute ischemic stroke[1][2]. |
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| Related Catalog | |
| In Vitro | Glenzocimab (0-100000 ng/mL) 抑制 GPVI-Fc 与固定在微量滴定板上的胶原蛋白结合，IC50 为 1.37 μg/mL[2]。 |
| In Vivo | Glenzocimab (1-8 mg/kg; i.v.) 抑制食蟹猴中胶原诱导的血小板聚集[2]。 Animal Model: Cynomolgus monkeys[2] Dosage: 1-8 mg/kg Administration: I.v. Result: Reversibly inhibited collagen-induced platelet aggregation, at 2 to 8 mg/kg doses, collagen-induced platelet aggregation measured 0.5 hour after the end of the administration was fully inhibited for all cynomolgus. |
| References |
| No Any Chemical & Physical Properties |