1257358-38-5

1257358-38-5 structure

1257358-38-5 structure

Name: gontivimab
Chemical Name: Gontivimab
CAS Number: 1257358-38-5
Molecular Formula:
Molecular Weight:
Catalog: Signaling Pathways Anti-infection RSV
Create Date: 2023-03-03 11:30:40
Modify Date: 2024-04-06 09:07:04
Gontivimab (ALX-0171; VR-465) is a poent anti-RSV prefusion F protein nanobody with a KD value of 0.113 nM. Gontivimab shows antiviral activity. Gontivimab reduces the RSV load in the nose and lung[1].

Name	Gontivimab

Description	Gontivimab (ALX-0171; VR-465) is a poent anti-RSV prefusion F protein nanobody with a KD value of 0.113 nM. Gontivimab shows antiviral activity. Gontivimab reduces the RSV load in the nose and lung[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> RSV
Target	KD: 0.113 nM (RSV prefusion F protein)[1]
In Vitro	Gontivimab (0-100000 nM) 显示出抗病毒活性，对 RSV-A、RSV-B 18537 菌株的 IC50 分别为 0.1、0.4 nM[1]。 Gontivimab 与 F 蛋白的抗原位点 II 结合[1]。
In Vivo	Gontivimab (1-68 mg/kg；鼻内给药或雾化) 降低大鼠鼻腔和肺部的 RSV 负荷[1]。 Animal Model: Rats (RSV Tracy)[1] Dosage: 1-68 mg/kg Administration: Intranasal administration or nebulization; once (day 2 or day 3) or twice (day 2 and day 3) Result: Resulted in significant viral load reductions in the lungs ranging.
References	[1]. Detalle L, et al. Generation and Characterization of ALX-0171, a Potent Novel Therapeutic Nanobody for the Treatment of Respiratory Syncytial Virus Infection. Antimicrob Agents Chemother. 2015 Oct 5;60(1):6-13.

No Any Chemical & Physical Properties