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1119807-02-1

1119807-02-1 structure

1119807-02-1 structure

Name: AZD5213
Chemical Name: AZD5213
CAS Number: 1119807-02-1
Molecular Formula: C₁₉H₂₅N₃O₂
Molecular Weight: 327.42
Catalog: Signaling Pathways GPCR/G Protein Histamine Receptor
Create Date: 2023-05-09 13:19:17
Modify Date: 2024-01-02 10:37:10
AZD5213 is a selective and competitive human H3 receptor antagonist with a pKi value of 9.3 for hH3R. AZD5213 can be used for the research of sleep and cognitive regulation[1][2].

Name	AZD5213

Description	AZD5213 is a selective and competitive human H3 receptor antagonist with a pKi value of 9.3 for hH3R. AZD5213 can be used for the research of sleep and cognitive regulation[1][2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
In Vivo	AZD5213 (1 mg/kg；静脉注射一次) 迅速减少 [11C] 4-(1S,2S)-2-(4-cyclobutylpiperazine-1-carbonyl)-cyclopropyl]-N-methyl-benzamide 与小鼠大脑所有区域的结合[1]。
References	[1]. Schou M, et al. Discovery and Preclinical Validation of [(11)C]AZ13153556, a Novel Probe for the Histamine Type 3 Receptor. ACS Chem Neurosci. 2016 Feb 17;7(2):177-84. [2]. Nikolic K, et al. Procognitive properties of drugs with single and multitargeting H3 receptor antagonist activities. CNS Neurosci Ther. 2014 Jul;20(7):613-23.

Molecular Formula	C₁₉H₂₅N₃O₂
Molecular Weight	327.42

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