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152538-59-5

152538-59-5 structure

152538-59-5 structure

Name: BTG 1640
Chemical Name: BTG 1640
CAS Number: 152538-59-5
Molecular Formula: C₁₅H₁₉NO₂
Molecular Weight: 245.32
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Chloride Channel
Create Date: 2023-05-09 19:47:55
Modify Date: 2024-04-03 21:31:00
BTG 1640 (ABIO-08/01) is a potent anxiolytic isoxazoline. BTG 1640 is a selective inhibitor of GABA- and glutamate-gated chloride channels[1].

Name	BTG 1640

Description	BTG 1640 (ABIO-08/01) is a potent anxiolytic isoxazoline. BTG 1640 is a selective inhibitor of GABA- and glutamate-gated chloride channels[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Chloride Channel Research Areas >> Neurological Disease
Target	GABA- and glutamate-gated chloride channels[1]
In Vivo	BTG 1640 (ABIO-08/01) 在小鼠和大鼠焦虑模型中单次腹腔注射和单次口服给药（灌胃）后，以极低剂量显示活性。长期给药既没有导致耐受性的发展，也没有在突然停止治疗后出现戒断症状[2]。
References	[1]. Correll CU, et al. The future of psychopharmacology: a critical appraisal of ongoing phase 2/3 trials, and of some current trends aiming to de-risk trial programmes of novel agents. World Psychiatry. 2023 Feb;22(1):48-74. [2]. Saletu-Zyhlarz GM, et al. Double-blind, placebo-controlled, multiple-ascending-dose study on the pharmacodynamics of ABIO-08/01, a new CNS drug with potential anxiolytic activity. 1. EEG mapping, psychometric and tolerability findings. Neuropsychobiology. 2009;59(2):100-9.

Molecular Formula	C₁₅H₁₉NO₂
Molecular Weight	245.32

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