2416740-37-7
2416740-37-7 structure
- Name: CD147 degrader 1
- Chemical Name: CD147 degrader 1
- CAS Number: 2416740-37-7
- Molecular Formula: C38H42N4O11
- Molecular Weight: 730.76
- Catalog: Signaling Pathways PROTAC PROTAC
- Create Date: 2023-04-10 11:31:07
- Modify Date: 2024-04-03 22:02:42
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CD147 degrader 1 is a PROTAC targets CD147 with an DC50 value of 6.72 µM. CD147 degrader 1 inhibits cell proliferation, migration and invasion. CD147 degrader 1 decreases the expression of CD147, MMP9, and p-STAT3 protein. CD147 degrader 1 shows anti-cancer acyivity[1].
| Name | CD147 degrader 1 |
|---|
| Description | CD147 degrader 1 is a PROTAC targets CD147 with an DC50 value of 6.72 µM. CD147 degrader 1 inhibits cell proliferation, migration and invasion. CD147 degrader 1 decreases the expression of CD147, MMP9, and p-STAT3 protein. CD147 degrader 1 shows anti-cancer acyivity[1]. |
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| Related Catalog | |
| In Vitro | CD147 degrader 1 (compound 6a) (2.5, 10 µM; 0, 24, 48 h) 抑制 Sk-Mel-28 细胞的迁移和侵袭[1]。 CD147 degrader 1 (0, 2.5, 5, 10 µM) 以剂量依赖性方式降低 CD147、MMP9 和 p-STAT3 蛋白的表达[1]。 Cell Cytotoxicity Assay[1] Cell Line: Sk-Mel-28 cells Concentration: 0-40 µM Incubation Time: 48 h Result: Exhibited cytotoxicity with an IC50 value of 6.23 µM. Western Blot Analysis[1] Cell Line: Sk-Mel-28, SK-Mel-5 cells Concentration: 0, 2.5, 5, 10 µM Incubation Time: 6 h Result: Decreased the expression of CD147, MMP9, p-STAT3 protein in a dose-dependent manner. |
| In Vivo | CD147 degrader 1 (20 mg/kg；腹腔注射；每两天一次，持续 17 天) 在小鼠体内显示出抗癌活性[1]。 Animal Model: 6-8 weeks, BALB/c female nude mice (Sk-Mel-5 cells)[1] Dosage: 20 mg/kg Administration: I.p.; every two days for 17 days Result: Significantly reduced volume and weight of tumors, and there was no noticeable weight loss. |
| References |
[1]. Zhou Z, et al. Targeted degradation of CD147 proteins in melanoma. Bioorg Chem. 2020 Dec;105:104453. |
| Molecular Formula | C38H42N4O11 |
|---|---|
| Molecular Weight | 730.76 |