1402931-76-3

1402931-76-3 structure

Name: eIF4A3-IN-12
Chemical Name: eIF4A3-IN-12
CAS Number: 1402931-76-3
Molecular Formula: C₂₇H₂₅ClO₇
Molecular Weight: 496.94
Catalog: Signaling Pathways Cell Cycle/DNA Damage Eukaryotic Initiation Factor (eIF)
Create Date: 2023-04-06 13:46:47
Modify Date: 2026-10-03 14:46:06
eIF4A3-IN-12 (compound 62) is a silvestrol (HY-13251) analogue. eIF4A3-IN-12 interferes the assembling of eIF4F translation complex with EC50s of 4, 70 and 5 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-12 can be used for the research of human cancer pathogenesis[1].

Name	eIF4A3-IN-12
Synonyms	1H-Cyclopenta[b]benzofuran-2-cboxylic acid, 6-chloro-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-, methyl ester, (1R,2R,3S,3,8bS)

Description	eIF4A3-IN-12 (compound 62) is a silvestrol (HY-13251) analogue. eIF4A3-IN-12 interferes the assembling of eIF4F translation complex with EC50s of 4, 70 and 5 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-12 can be used for the research of human cancer pathogenesis[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Eukaryotic Initiation Factor (eIF)
References	[1]. Liu T, et al. Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors. J Med Chem. 2012 Oct 25;55(20):8859-78.

Molecular Formula	C₂₇H₂₅ClO₇
Molecular Weight	496.94