2413192-59-1

2413192-59-1 structure

Name: HBV-IN-29
Chemical Name: HBV-IN-29
CAS Number: 2413192-59-1
Molecular Formula: C₂₂H₁₉ClO₆
Molecular Weight: 414.84
Catalog: Signaling Pathways Anti-infection HBV
Create Date: 2023-04-05 12:55:13
Modify Date: 2024-01-02 18:28:41
HBV-IN-29 (ex8), a flavone derivative, is a potent covalently closed circular DNA (cccDNA) inhibitor. cccDNA serves as the template for viral RNA transcription and subsequent viral DNA generation. HBV-IN-29 has the potential for the research of HBV infection[1].

Name	HBV-IN-29

Description	HBV-IN-29 (ex8), a flavone derivative, is a potent covalently closed circular DNA (cccDNA) inhibitor. cccDNA serves as the template for viral RNA transcription and subsequent viral DNA generation. HBV-IN-29 has the potential for the research of HBV infection[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> HBV
In Vitro	HBV-IN-29 (ex8; 24 h) 在 HepDES19 细胞中抑制 HBeAg 水平和细胞活力，IC50 值为 1.34 μM。HepDES19 是产生 cccDNA 的细胞系[1]。 HBV-IN-29 (5 days) 以剂量依赖性方式降低 HepDES19 细胞中的 cccDNA 水平[1]。 HBV-IN-29 (9 天; 原代人肝细胞 (PHH)) 具有抗 HBV 作用并抑制 HBeAg，IC50 值为 0.12 μM[1]。
References	[1]. Song F, et, al. Flavone compounds for the treatment and prophylaxis of hepatitis b virus disease. WO2020053249.

Molecular Formula	C₂₂H₁₉ClO₆
Molecular Weight	414.84