1001670-19-4
1001670-19-4 structure
- Name: Lagociclovir valactate
- Chemical Name: Lagociclovir valactate
- CAS Number: 1001670-19-4
- Molecular Formula: C19H27FN6O6
- Molecular Weight: 454.45
- Catalog: Signaling Pathways Anti-infection HBV
- Create Date: 2023-04-07 11:02:54
- Modify Date: 2024-04-02 23:03:53
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Lagociclovir valactate is a prodrug of Lagociclovir (HY-14844). Lagociclovir valactate is an orally active anti-HBV agent[1].
| Name | Lagociclovir valactate |
|---|
| Description | Lagociclovir valactate is a prodrug of Lagociclovir (HY-14844). Lagociclovir valactate is an orally active anti-HBV agent[1]. |
|---|---|
| Related Catalog | |
| Target |
HBV[1] |
| In Vivo | Lagociclovir valactate (20 or 60 mg/kg; p.o.; daily for 10 weeks) 在土拨鼠中显示抗土拨鼠肝炎病毒 (WHV) 活性[1]。 Animal Model: Woodchucks with chronic WHV infection[1] Dosage: 20 or 60 mg/kg Administration: Oral, daily for 10 weeks Result: Reduced WHV viremia effectively and maintained WHV DNA at a very low level. Animal Model: Woodchucks[1] Dosage: 10 or 40 mg/kg Administration: Oral (Pharmacokinetic Analysis) Result: Average pharmacokinetic parameters for Lagociclovir after oral administration of Lagociclovir valactate to healthy and chronically WHV infected woodchucks[1] Pharmacokineticparameter for Lagociclovir Healthy woodchucks (n = 4) receiving Lagociclovir valactate at 10 mg/kg Healthy woodchucks (n = 4) receiving Lagociclovir valactate at 40 mg/kg WHV-infected woodchucks (n = 14) receiving Lagociclovir valactate at 60 mg/kg Cmax (μM) 0.54 ± 0.14 2.10 ± 1.5 3.50 ± 1.9 Tmax (h) 4.10 ± 1.0 3.30 ± 1.5 2.90 ± 1.1 AUC0-∞ (μM • h/liter) 5.15 ± 1.0 10.50 ± 4.2 20.1 ± 11.3 t1/2 (h) 5.44 ± 1.2 4.20 ± 1.6 4.7 ± 0.8 |
| References |
| Molecular Formula | C19H27FN6O6 |
|---|---|
| Molecular Weight | 454.45 |