2428381-55-7
2428381-55-7 structure
- Name: Ligufalimab
- Chemical Name: Ligufalimab
- CAS Number: 2428381-55-7
- Molecular Formula:
- Molecular Weight:
- Catalog: Signaling Pathways Immunology/Inflammation Interleukin Related
- Create Date: 2023-05-15 19:32:30
- Modify Date: 2024-01-13 11:20:23
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Ligufalimab (AK 117) is a humanized IgG4 anti-CD47 monoclonal antibody. Ligufalimab does not induce RBC hemagglutination, and induces phagocytosis. Ligufalimab shows anti-tumor activity[1].
| Name | Ligufalimab |
|---|
| Description | Ligufalimab (AK 117) is a humanized IgG4 anti-CD47 monoclonal antibody. Ligufalimab does not induce RBC hemagglutination, and induces phagocytosis. Ligufalimab shows anti-tumor activity[1]. |
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| Related Catalog | |
| In Vitro | Ligufalimab 结合人 CD47 抗原，EC50 值为 0.078 nM，KD 值为 0.152 nM[1]。 Ligufalimab (0-3000 nM) 不诱导红细胞血凝[1]。 Ligufalimab (0.1、1、10 µg/mL) 以剂量依赖性方式诱导 Raji、Jurkat 和 Ramos 细胞的吞噬作用[1]。 |
| In Vivo | Ligufalimab(0.1, 1 mg/kg for Raji xenograft, 0.2 mg/kg for MDA-MB-231 xenograft model) 抑制小鼠肿瘤生长[1]。 Animal Model: SCID/Beige mice (Raji xenograft model, MDA-MB-231 xenograft model)[1] Dosage: 0.1, 1 mg/kg for Raji xenograft, 0.2 mg/kg for MDA-MB-231 xenograft model Administration: I.v. Result: Inhibited tumor growth with the tumor inhibition rate of 88.56%, 63.78% at 1, 0.1 mg/kg. |
| References |
| No Any Chemical & Physical Properties |