413605-11-5

413605-11-5 structure

413605-11-5 structure

Name: LP-471756
Chemical Name: LP-471756
CAS Number: 413605-11-5
Molecular Formula: C₁₉H₂₃NO₂S
Molecular Weight: 329.46
Catalog: Signaling Pathways GPCR/G Protein GPR139
Create Date: 2023-04-02 18:14:15
Modify Date: 2023-04-02 18:14:15
LP-471756 is a potent GPR139 antagonist with an IC50 value of 640 nM. LP-471756 inhibits LP-360924-stimulated cAMP production[1][2].

Name	LP-471756

Description	LP-471756 is a potent GPR139 antagonist with an IC50 value of 640 nM. LP-471756 inhibits LP-360924-stimulated cAMP production[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> GPR139 Research Areas >> Neurological Disease
Target	IC50: 640 nM (GPR139)[1]
In Vitro	LP-471756 (0-1000 µM) 特异性抑制 GPR139 细胞中 LP-360924 刺激的 cAMP 的生成，IC50 值为 0.64 µM[2]。
References	[1]. Vedel L, et al. Pharmacology and function of the orphan GPR139 G protein-coupled receptor. Basic Clin Pharmacol Toxicol. 2020 Jun;126 Suppl 6(Suppl 6):35-46. [2]. Hu LA, et al. Identification of surrogate agonists and antagonists for orphan G-protein-coupled receptor GPR139. J Biomol Screen. 2009 Aug;14(7):789-97.

Molecular Formula	C₁₉H₂₃NO₂S
Molecular Weight	329.46