2727872-68-4
2727872-68-4 structure
- Name: SRI-42127
- Chemical Name: SRI-42127
- CAS Number: 2727872-68-4
- Molecular Formula: C19H20N6O
- Molecular Weight: 348.40
- Catalog: Signaling Pathways Immunology/Inflammation Interleukin Related
- Create Date: 2023-04-29 11:31:58
- Modify Date: 2024-02-06 09:49:59
-
SRI-42127 is a HuR translocation inhibitor. HuR is an RNA regulator that binds to AREs, and HuR translocations promote the production of inflammatory cytokines in glial cells. However, SRI-42127 can destroy mRNA stability and inhibit gene promoter activation. SRI-42127 also inhibits microglial cell activation and attenuates recruitment/chemotaxis of neutrophils and monocytes[1].
| Name | SRI-42127 |
|---|
| Description | SRI-42127 is a HuR translocation inhibitor. HuR is an RNA regulator that binds to AREs, and HuR translocations promote the production of inflammatory cytokines in glial cells. However, SRI-42127 can destroy mRNA stability and inhibit gene promoter activation. SRI-42127 also inhibits microglial cell activation and attenuates recruitment/chemotaxis of neutrophils and monocytes[1]. |
|---|---|
| Related Catalog | |
| Target |
HuR[1] |
| In Vitro | SRI-42127 (0.05-1 μM; 24 h) 阻断 LPS (1 μg/mL) 刺激原代小胶质细胞的 HuR 细胞质转位[1]。 SRI-42127 (0.05-1 μM; 24 h) 抑制激活的原代小胶质细胞 (PMG) 中炎症细胞因子和趋化因子 mRNA 水平[1]。 SRI-42127 (0.5 μM 和 1 μM; 24 h) 阻断胶质细胞产生的中性粒细胞和单核细胞的化学吸引/迁移信号[1]。 |
| In Vivo | SRI-42127 (15 mg/kg; 腹腔注射; 单剂量) 抑制小鼠模型中 HuR 易位和小胶质细胞活化[1]。 |
| References |
| Molecular Formula | C19H20N6O |
|---|---|
| Molecular Weight | 348.40 |