17829-03-7

17829-03-7 structure

Name: 7-Methylguanine-d3
Chemical Name: 7-Methylguanine-d3
CAS Number: 17829-03-7
Molecular Formula: C₆H₄D₃N₅O
Molecular Weight: 168.17
Catalog: Research Areas Others
Create Date: 2023-04-25 17:52:52
Modify Date: 2024-04-01 18:45:35
7-Methylguanine-d3 is the deuterium labeled 7-Methylguanine[1]. 7-Methylguanine is a metabolite of DNA methylation. It can be generated by methylating agents, and used as a probe of protein–DNA interactions and a key component of DNA sequencing method[2].

Name	7-Methylguanine-d3

Description	7-Methylguanine-d3 is the deuterium labeled 7-Methylguanine[1]. 7-Methylguanine is a metabolite of DNA methylation. It can be generated by methylating agents, and used as a probe of protein–DNA interactions and a key component of DNA sequencing method[2].
Related Catalog	Research Areas >> Others
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Lee S, et al. Synthesis and structure of duplex DNA containing the genotoxic nucleobase lesion N7-methylguanine. J Am Chem Soc. 2008 Sep 3;130(35):11570-1.

Molecular Formula	C₆H₄D₃N₅O
Molecular Weight	168.17