209394-18-3

209394-18-3 structure

Name: Ladostigil hydrochloride
Chemical Name: Ladostigil hydrochloride
CAS Number: 209394-18-3
Molecular Formula: C₁₆H₂₁ClN₂O₂
Molecular Weight: 308.80
Catalog: Signaling Pathways Neuronal Signaling AChE
Create Date: 2023-04-25 19:10:04
Modify Date: 2025-08-26 19:28:46
Ladostigil (TV-3326) hydrochloride is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO), with IC50s of 37.1 and 31.8 μM for MAO-B and AChE, respectively. Ladostigil hydrochloride exhibits neuroprotective, antioxidant and anti-inflammatory activities. Ladostigil can be used for the research of depression and Alzheimer's disease[1][2].

Name	Ladostigil hydrochloride

Description	Ladostigil (TV-3326) hydrochloride is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO), with IC50s of 37.1 and 31.8 μM for MAO-B and AChE, respectively. Ladostigil hydrochloride exhibits neuroprotective, antioxidant and anti-inflammatory activities. Ladostigil can be used for the research of depression and Alzheimer's disease[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE
Target	AChE:31.8 μM (IC50) MAO-B:37.1 μM (IC50)
In Vitro	Ladostigil (1-10 µM) hydrochloride 具有神经保护活性，包括防止线粒体膜电位 (ψ) 下降，衰减凋亡级联和抑制 OS 损伤诱导的 ROS 产生[2]。 Ladostigil (1-10 µM) hydrochloride 具有显著的神经保护活性，包括抑制 caspase-3 激活，诱导 Bcl-2，降低人成神经细胞瘤 SK-N-SH 细胞中 Bad 和 Bax 基因和蛋白的表达[2]。
In Vivo	Ladostigil (17 mg/kg; p.o. daily for 6 weeks) hydrochloride 在从青春期到产前压力大鼠的成年期的高架十字迷宫 (EPM) 和强迫游泳测试 (FST) 测试中，消除了他们的高度焦虑和抑郁样行为[4]。 Ladostigil (50 μmol/kg; single p.o.) hydrochloride 在大鼠物体识别测试中恢复丧失的情景记忆[3]。 Animal Model: Pathogen-free (SPF) Sprague-Dawley rats[4] Dosage: 17 mg/kg Administration: Oral (added to the drinking water) daily for 6 weeks Result: Inhibited brain MAO-A and B by more than 60%. Reduced hyperanxiety of male and female prenatally stressed (PS) rats in the EPM and depressive-like behaviour in the FST.
References	[1]. Denya I, et, al. Design, synthesis and evaluation of indole derivatives as multifunctional agents against Alzheimer's disease. Medchemcomm. 2018 Jan 16; 9(2):357-370. [2]. Weinreb O, et, al. Ladostigil: a novel multimodal neuroprotective drug with cholinesterase and brain-selective monoamine oxidase inhibitory activities for Alzheimer's disease treatment. Curr Drug Targets. 2012 Apr; 13(4): 483-94. [3]. Weinstock M, et, al. Ladostigil, a novel multifunctional drug for the treatment of dementia co-morbid with depression. J Neural Transm Suppl. 2006; (70):443-6. [4]. Poltyrev T, et, al. Effect of chronic treatment with ladostigil (TV-3326) on anxiogenic and depressive-like behaviour and on activity of the hypothalamic-pituitary-adrenal axis in male and female prenatally stressed rats. Psychopharmacology (Berl). 2005 Aug;181(1): 118-25.

Molecular Formula	C₁₆H₂₁ClN₂O₂
Molecular Weight	308.80

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

209394-18-3	1406-14-0
6138-79-0	127228-87-9
143851-98-3	929-73-7
65546-09-0	1135280-78-2
56-99-5	1406-02-6
933734-58-8	1785291-11-3
1314710-55-8	146580-39-4
1368012-13-8	1515966-54-7
1368012-06-9	1779831-32-1
2648994-07-2	1416017-49-6