2891860-17-4

2891860-17-4 structure
2891860-17-4 structure
  • Name: SHR-1701
  • Chemical Name: SHR-1701
  • CAS Number: 2891860-17-4
  • Molecular Formula:
  • Molecular Weight:
  • Catalog: Signaling Pathways Immunology/Inflammation PD-1/PD-L1
  • Create Date: 2023-04-21 12:05:39
  • Modify Date: 2024-04-03 10:48:59
  • SHR-1701 (Retlirafusp alfa) is a bifunctional fusion protein targeting PD-L1 and TGF-β for cancer research[1].

Name SHR-1701
Description SHR-1701 (Retlirafusp alfa) is a bifunctional fusion protein targeting PD-L1 and TGF-β for cancer research[1].
Related Catalog
In Vitro SHR-1701 (10 μg/mL)可以抑制 TGF-β 信号通路,激活 PI3K/Akt/Erk 信号通路,挽救淋巴细胞恢复受损的肺癌患者外周血CD8+ T 细胞的抗肿瘤功能[1]。
References

[1]. Bo Cheng, et al. Anti-PD-L1/TGF-βR fusion protein (SHR-1701) overcomes disrupted lymphocyte recovery-induced resistance to PD-1/PD-L1 inhibitors in lung cancer. Cancer Commun (Lond). 2022 Jan;42(1):17-36.  

No Any Chemical & Physical Properties