824960-50-1

824960-50-1 structure
824960-50-1 structure
  • Name: WDR5-0102
  • Chemical Name: WDR5-0102
  • CAS Number: 824960-50-1
  • Molecular Formula: C18H19ClN4O3
  • Molecular Weight: 374.82
  • Catalog: Research Areas Cancer
  • Create Date: 2023-05-31 18:48:04
  • Modify Date: 2024-07-17 23:00:56
  • WDR5-0102 is an inhibitor targeting WDR5-MLL1 interface (Kdis=7 μM, Kd=4 μM). WDR5-0102 suppresses MLL1 HMT activity, but not human H3K4 methyltransferase SETD7 and six other HMTs: G9a, EHMT1, SUV39H2, SETD8, PRMT3, and PRMT5[1][2].

Name WDR5-0102
Description WDR5-0102 is an inhibitor targeting WDR5-MLL1 interface (Kdis=7 μM, Kd=4 μM). WDR5-0102 suppresses MLL1 HMT activity, but not human H3K4 methyltransferase SETD7 and six other HMTs: G9a, EHMT1, SUV39H2, SETD8, PRMT3, and PRMT5[1][2].
Related Catalog
References

[1]. Ye X, et al. The identification of novel small-molecule inhibitors targeting WDR5-MLL1 interaction through fluorescence polarization based high-throughput screening. Bioorg Med Chem Lett. 2019 Feb 15;29(4):638-645.  

[2]. Chen X, et al. Targeting WD Repeat-Containing Protein 5 (WDR5): A Medicinal Chemistry Perspective. J Med Chem. 2021 Aug 12;64(15):10537-10556.  

Molecular Formula C18H19ClN4O3
Molecular Weight 374.82