2567494-39-5
2567494-39-5 structure
- Name: Crozbaciclib fumarate
- Chemical Name: Crozbaciclib fumarate
- CAS Number: 2567494-39-5
- Molecular Formula: C32H34F2N6O4
- Molecular Weight: 604.65
- Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
- Create Date: 2023-07-09 17:01:18
- Modify Date: 2024-09-09 13:23:44
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Crozbaciclib fumarate is a CDK4/6 inhibitor with IC50s of 3 and 1 nM, respectively.
| Name | Crozbaciclib fumarate |
|---|
| Description | Crozbaciclib fumarate is a CDK4/6 inhibitor with IC50s of 3 and 1 nM, respectively. |
|---|---|
| Related Catalog | |
| Target |
IC50: 3 nM (CDK4), 1 nM (CDK6)[1] |
| In Vitro | Crozbaciclib fumarate 是一种有效的抗增殖剂，可将 U87MG 细胞系完全抑制在 G1 期（抗增殖试验中的 IC50=15.3 ± 2.9 nM）。 Crozbaciclib fumarate (13.72 nM; 24 h)显着增加 U87MG 细胞中 G1 期细胞的百分比[1]。 |
| In Vivo | Crozbaciclib fumarate (3.125-50 mg/kg) 在多形性胶质母细胞瘤原位异种移植小鼠模型中具有 62% 至 99% 的肿瘤生长抑制值。 而 Crozbaciclib fumarate 导致体重减轻不明显。 在 50 mg/kg[1] 的剂量下，Crozbaciclib fumarate 显着延长了 162% 的小鼠中载体处理动物的平均存活时间，显着延长了寿命。 |
| References |
| Molecular Formula | C32H34F2N6O4 |
|---|---|
| Molecular Weight | 604.65 |