177075-18-2

177075-18-2 structure

177075-18-2 structure

Name: ISIS 5132
Chemical Name: ISIS 5132
CAS Number: 177075-18-2
Molecular Formula:
Molecular Weight:
Catalog: Signaling Pathways MAPK/ERK Pathway Raf
Create Date: 2023-06-23 16:10:01
Modify Date: 2024-04-03 12:06:58
ISIS 5132 is a 20-base phosphorothioate oligonucleotide that specifically down-regulates c-raf expression.

Name	ISIS 5132

Description	ISIS 5132 is a 20-base phosphorothioate oligonucleotide that specifically down-regulates c-raf expression.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> Raf
References	[1]. Rudin CM, Holmlund J, Fleming GF, et al. Phase I Trial of ISIS 5132, an antisense oligonucleotide inhibitor of c-raf-1, administered by 24-hour weekly infusion to patients with advanced cancer. Clin Cancer Res. 2001;7(5):1214-1220. [2]. Tolcher AW, Reyno L, Venner PM, et al. A randomized phase II and pharmacokinetic study of the antisense oligonucleotides ISIS 3521 and ISIS 5132 in patients with hormone-refractory prostate cancer. Clin Cancer Res. 2002;8(8):2530-2535.

No Any Chemical & Physical Properties