2803881-11-8

2803881-11-8 structure

Name: MRT-2359
Chemical Name: MRT-2359
CAS Number: 2803881-11-8
Molecular Formula: C₂₂H₁₇F₄N₃O₆
Molecular Weight: 495.38
Catalog: Research Areas Cancer
Create Date: 2023-06-27 17:49:08
Modify Date: 2024-01-09 16:24:28
MRT-2359 is an orally active and potent degrader of GSPT1 with anti-tumor activity. MRT-2359 also inhibits the growth of resistant non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) cells. MRT-2359 exhibits preferential activity in MYC-driven cell lines, such as N- and L-MYC high NSCLC and SCLC patient-derived xenografts (PDXs)[1].

Name	MRT-2359

Description	MRT-2359 is an orally active and potent degrader of GSPT1 with anti-tumor activity. MRT-2359 also inhibits the growth of resistant non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) cells. MRT-2359 exhibits preferential activity in MYC-driven cell lines, such as N- and L-MYC high NSCLC and SCLC patient-derived xenografts (PDXs)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	GSPT1[1]
References	[1]. Gavory G, et al. Development of MRT-2359, an orally bioavailable GSPT1 molecular glue degrader, for the treatment of lung cancers with MYC-induced translational addiction[J]. Cancer Research, 2023, 83(7_Supplement): 3449-3449.

Molecular Formula	C₂₂H₁₇F₄N₃O₆
Molecular Weight	495.38