1259177-59-7

1259177-59-7 structure

Name: Myosin V-IN-1
Chemical Name: Myosin V-IN-1
CAS Number: 1259177-59-7
Molecular Formula: C₂₉H₂₆N₆O₃S
Molecular Weight: 538.62
Catalog: Signaling Pathways Cytoskeleton Myosin
Create Date: 2023-06-20 18:34:35
Modify Date: 2024-01-19 17:34:44
Myosin V-IN-1 (compound 8) is a potent and selective Myosin V inhibitor, with a Ki of 6 μM. Myosin V-IN-1 shows acute inhibition of myosin V. Myosin V-IN-1 slows the actin-activated myosin V ATPase by specifically inhibiting ADP release from the actomyosin complex[1][2].

Name	Myosin V-IN-1

Description	Myosin V-IN-1 (compound 8) is a potent and selective Myosin V inhibitor, with a Ki of 6 μM. Myosin V-IN-1 shows acute inhibition of myosin V. Myosin V-IN-1 slows the actin-activated myosin V ATPase by specifically inhibiting ADP release from the actomyosin complex[1][2].
Related Catalog	Signaling Pathways >> Cytoskeleton >> Myosin Research Areas >> Neurological Disease
In Vitro	Myosin V-IN-1 (compound 8) 显示出单头肌球蛋白 V 稳态肌动蛋白激活 ATP 水解速率的剂量依赖性降低[1]。
References	[1]. Maschi D, et al. Myosin V Regulates Spatial Localization of Different Forms of Neurotransmitter Release in Central Synapses. Front Synaptic Neurosci. 2021 Apr 15;13:650334. [2]. Islam K, et al. A myosin V inhibitor based on privileged chemical scaffolds. Angew Chem Int Ed Engl. 2010 Nov 2;49(45):8484-8.

Molecular Formula	C₂₉H₂₆N₆O₃S
Molecular Weight	538.62