338419-11-7

338419-11-7 structure
338419-11-7 structure
  • Name: Notum-IN-1
  • Chemical Name: Notum-IN-1
  • CAS Number: 338419-11-7
  • Molecular Formula: C9H7Cl2N3O
  • Molecular Weight: 244.08
  • Catalog: Research Areas Cancer
  • Create Date: 2023-06-27 22:44:05
  • Modify Date: 2025-08-27 11:06:05
  • Notum-IN-1 (compound 6b) is an orally active, selective and brain penetrant inhibitor of Notum. Notum-IN-1 blocks the Wnt signaling in vivo in mouse[1].

Name Notum-IN-1
Description Notum-IN-1 (compound 6b) is an orally active, selective and brain penetrant inhibitor of Notum. Notum-IN-1 blocks the Wnt signaling in vivo in mouse[1].
Related Catalog
Target

Notum[1]

References

[1]. Willis NJ, et al. Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit. J Med Chem. 2022 May 26;65(10):7212-7230.  

Molecular Formula C9H7Cl2N3O
Molecular Weight 244.08
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