2719001-44-0
2719001-44-0 structure
- Name: STING agonist-31
- Chemical Name: STING agonist-31
- CAS Number: 2719001-44-0
- Molecular Formula: C43H51N15O6
- Molecular Weight: 873.96
- Catalog: Signaling Pathways Immunology/Inflammation STING
- Create Date: 2023-06-10 23:03:17
- Modify Date: 2024-01-18 18:04:42
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STING agonist-31 is a STING agonist, with EC50 values of 0.24 and 39.51 μM for h-STING and m-STING. STING agonist-31 has antitumor efficiency[1].
| Name | STING agonist-31 |
|---|
| Description | STING agonist-31 is a STING agonist, with EC50 values of 0.24 and 39.51 μM for h-STING and m-STING. STING agonist-31 has antitumor efficiency[1]. |
|---|---|
| Related Catalog | |
| In Vitro | STING agonist-31 (化合物 40) 激活 h-STING 和 m-STING，EC50 值为 0.24 和 39.51 μM[1]。 STING agonist-31 (0-10 μM，24 h) 激活 ISG 信号和 NF-κB 信号[1]。 |
| In Vivo | STING agonist-31 (化合物 40) (10 mg/kg，静脉注射) 抑制 4T1 和 CT26 小鼠肿瘤模型中的肿瘤生长[1]。 STING agonist-31 (1 mg/kg，静脉注射) 在大鼠中显示出 T1/2：0.697 h，AUClast 678 h•ng/mL[1]< /sup>. Animal Model: Mice models bearing orthotopic transplanted breast tumor (4T1) or subcutaneous transplanted colon tumor (CT26)[1] Dosage: 10 mg/kg Administration: i.v., at days 1, 4, and 7 Result: Inhibited tumor Growth. |
| References |
| Molecular Formula | C43H51N15O6 |
|---|---|
| Molecular Weight | 873.96 |