2918803-89-9
2918803-89-9 structure
- Name: TRPV4 antagonist 4
- Chemical Name: TRPV4 antagonist 4
- CAS Number: 2918803-89-9
- Molecular Formula: C28H32Cl2N6O
- Molecular Weight: 539.50
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel TRP Channel
- Create Date: 2023-05-31 18:39:31
- Modify Date: 2025-08-20 18:41:37
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TRPV4 antagonist 4 is a potent TRPV4 antagonist with an IC50 value of 22.65 nM. TRPV4 antagonist 4 inhibits TRPV4 current. TRPV4 antagonist 4 shows protective effects on acute lung injury[1].
| Name | TRPV4 antagonist 4 |
|---|
| Description | TRPV4 antagonist 4 is a potent TRPV4 antagonist with an IC50 value of 22.65 nM. TRPV4 antagonist 4 inhibits TRPV4 current. TRPV4 antagonist 4 shows protective effects on acute lung injury[1]. |
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| Related Catalog | |
| Target |
TRPV4:22.65 nM (IC50) |
| In Vitro | TRPV4 antagonist 4 (compound 2b; 1 µM) 抑制 TRPV4-CHO 细胞中 GSK1016790A (HY-19608) (100 nM) 诱导的 TRPV4 全细胞电流[1]。 TRPV4 antagonist 4 抑制 HUVEC 中对 LPS (HY-D1056) 诱导的通透性反应[1]。 |
| In Vivo | TRPV4 antagonist 4 (1 mg/kg; i.p.) 在 LPS 诱导的小鼠肺损伤模式中改善肺水肿和相关肺病理变化[1]。 Animal Model: Mice (acute lung injury (ALI))[1] Dosage: 1 mg/kg Administration: I,p.; before LPS inhalation Result: Displayed significant effects to reduce the lung W/D ratio and significantly decreased the concentrations of BALF protein, significantly blocked the permeability response to LPS stimulates, greatly improved the pneumonedema, the lung pathologic changes in LPS-induced mouse lung injury mode. |
| References |
| Molecular Formula | C28H32Cl2N6O |
|---|---|
| Molecular Weight | 539.50 |