871978-21-1

871978-21-1 structure

Name: AM841
Chemical Name: AM841
CAS Number: 871978-21-1
Molecular Formula: C₂₆H₃₉NO₃S
Molecular Weight: 445.66
Catalog: Signaling Pathways GPCR/G Protein Cannabinoid Receptor
Create Date: 2023-09-24 06:14:46
Modify Date: 2024-01-11 17:52:22
AM841 is a high-affinity electrophilic ligand. AM841 interacts covalently with a cysteine in helix six and activates the CB1 cannabinoid receptor. AM841 reduces Forskolin (HY-15371)-stimulated cAMP accumulation. AM841 also slows gastrointestinal motility[1][2].

Name	AM841

Description	AM841 is a high-affinity electrophilic ligand. AM841 interacts covalently with a cysteine in helix six and activates the CB1 cannabinoid receptor. AM841 reduces Forskolin (HY-15371)-stimulated cAMP accumulation. AM841 also slows gastrointestinal motility[1][2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor
References	[1]. Picone RP, et al. (-)-7'-Isothiocyanato-11-hydroxy-1',1'-dimethylheptylhexahydrocannabinol (AM841), a high-affinity electrophilic ligand, interacts covalently with a cysteine in helix six and activates the CB1 cannabinoid receptor. Mol Pharmacol. 2005 Dec;68(6):1623-35. [2]. Keenan CM, et al. AM841, a covalent cannabinoid ligand, powerfully slows gastrointestinal motility in normal and stressed mice in a peripherally restricted manner. Br J Pharmacol. 2015 May;172(9):2406-18.

Molecular Formula	C₂₆H₃₉NO₃S
Molecular Weight	445.66