1397683-26-9

1397683-26-9 structure

Name: BACE1-IN-13
Chemical Name: BACE1-IN-13
CAS Number: 1397683-26-9
Molecular Formula: C₂₀H₁₇FN₈O₂
Molecular Weight: 420.40
Catalog: Signaling Pathways Neuronal Signaling Beta-secretase
Create Date: 2023-10-22 20:07:34
Modify Date: 2024-01-28 11:04:17
BACE1-IN-13 (Compound 36) is an orally active BACE1 inhibitor with an IC50 value of 2.9 nM. BACE1-IN-13 is highly potent in hAβ42 cell (IC50 = 1.3 nM). BACE1-IN-13 has cardiovascularly safty and elicits sustained Aβ42 reduction in mouse and dog animal models[1].

Name	BACE1-IN-13

Description	BACE1-IN-13 (Compound 36) is an orally active BACE1 inhibitor with an IC50 value of 2.9 nM. BACE1-IN-13 is highly potent in hAβ42 cell (IC50 = 1.3 nM). BACE1-IN-13 has cardiovascularly safty and elicits sustained Aβ42 reduction in mouse and dog animal models[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Beta-secretase Research Areas >> Neurological Disease
Target	IC50: 1.3 nM (hAβ42 cell)[1].
References	[1]. Peschiulli A, et al. A Brain-Penetrant and Bioavailable Pyrazolopiperazine BACE1 Inhibitor Elicits Sustained Reduction of Amyloid β In Vivo. ACS Med Chem Lett. 2021 Dec 1;13(1):76-83.

Molecular Formula	C₂₀H₁₇FN₈O₂
Molecular Weight	420.40