2568086-81-5

2568086-81-5 structure

Name: EGFR-IN-82
Chemical Name: EGFR-IN-82
CAS Number: 2568086-81-5
Molecular Formula: C₃₂H₄₁BrN₉O₂P
Molecular Weight: 694.60
Catalog: Signaling Pathways JAK/STAT Signaling EGFR
Create Date: 2023-09-18 09:31:31
Modify Date: 2024-01-12 08:05:19
EGFR-IN-82 (Cmpound 8a) is a potent and orally active EGFR inhibitor with IC50 values of 0.09 and 0.06 nM for EGFRL858R/T790M/C797S and EGFRDel19/T790M/C797S, respectively. EGFR-IN-82 has no significant effect on EGFRWT. EGFR-IN-82 has anti-proliferative activity and inhibits tumor formation in nude mice. EGFR-IN-82 can be used in non-small cell lung cancer research [1].

Name	EGFR-IN-82

Description	EGFR-IN-82 (Cmpound 8a) is a potent and orally active EGFR inhibitor with IC50 values of 0.09 and 0.06 nM for EGFRL858R/T790M/C797S and EGFRDel19/T790M/C797S, respectively. EGFR-IN-82 has no significant effect on EGFRWT. EGFR-IN-82 has anti-proliferative activity and inhibits tumor formation in nude mice. EGFR-IN-82 can be used in non-small cell lung cancer research [1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Target	0.09 , 0.06 nM (EGFRL858R/T790M/C797S, EGFRDel19/T790M/C797S)
References	[1]. 1. Yanliang Guo, et al. Design, synthesis and biological evaluation of phosphoroxy quinazoline derivatives as potential EGFRT790M/C797S inhibitors. Bioorganic & Medicinal Chemistry. Volume 90, 15 July 2023, 117338.

Molecular Formula	C₃₂H₄₁BrN₉O₂P
Molecular Weight	694.60