824983-90-6

824983-90-6 structure

Name: FEN1-IN-7
Chemical Name: FEN1-IN-7
CAS Number: 824983-90-6
Molecular Formula: C₁₆H₁₄N₂O₆S
Molecular Weight: 362.36
Catalog: Signaling Pathways Immunology/Inflammation FLAP
Create Date: 2023-10-17 18:36:06
Modify Date: 2024-01-19 11:58:48
FEN1-IN-7 (compound 16) is a selective inhibitor of Flap endonuclease-1 (FEN1, IC50=18 nM), involving in mammalian cells to repair DNA damage. FEN1-IN-7 also targets to related endonuclease, xeroderma pigmentosum G (XPG) with an IC50 value of 3.04 μM. FEN1-IN-7 increases the cellular sensitivity of cancer cells to potent DNA alkylating agents or methylating agents[1].

Name	FEN1-IN-7

Description	FEN1-IN-7 (compound 16) is a selective inhibitor of Flap endonuclease-1 (FEN1, IC50=18 nM), involving in mammalian cells to repair DNA damage. FEN1-IN-7 also targets to related endonuclease, xeroderma pigmentosum G (XPG) with an IC50 value of 3.04 μM. FEN1-IN-7 increases the cellular sensitivity of cancer cells to potent DNA alkylating agents or methylating agents[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> FLAP
References	[1]. Tumey LN, et al. The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors. Bioorg Med Chem Lett. 2005 Jan 17;15(2):277-81.

Molecular Formula	C₁₆H₁₄N₂O₆S
Molecular Weight	362.36