2043343-94-6

2043343-94-6 structure

Name: Mosnodenvir
Chemical Name: Mosnodenvir
CAS Number: 2043343-94-6
Molecular Formula: C₂₆H₂₂ClF₃N₂O₆S
Molecular Weight: 582.98
Catalog: Research Areas Infection
Create Date: 2023-09-19 17:00:20
Modify Date: 2024-01-21 10:27:21
Mosnodenvir (JNJ-1802) is a pan-serotype dengue antiviral agent with a high barrier to resistance, and is safe and well-tolerated. Mosnodenvir blocks the NS3-NS4B interaction within the viral replication complex. Mosnodenvir shows picomolar to low nanomolar in vitro antiviral activity in mice[1][2].

Name	Mosnodenvir

Description	Mosnodenvir (JNJ-1802) is a pan-serotype dengue antiviral agent with a high barrier to resistance, and is safe and well-tolerated. Mosnodenvir blocks the NS3-NS4B interaction within the viral replication complex. Mosnodenvir shows picomolar to low nanomolar in vitro antiviral activity in mice[1][2].
Related Catalog	Research Areas >> Infection
References	[1]. Ackaert O, et al. Safety, tolerability and pharmacokinetics of JNJ-1802, a pan-serotype dengue direct antiviral small molecule, in a Phase 1, double-blind, randomized, dose-escalation study in healthy volunteers. Clin Infect Dis. 2023 May 10:ciad284. [2]. Goethals O, et al. Blocking NS3-NS4B interaction inhibits dengue virus in non-human primates. Nature. 2023 Mar;615(7953):678-686.

Molecular Formula	C₂₆H₂₂ClF₃N₂O₆S
Molecular Weight	582.98