2642037-07-6

2642037-07-6 structure

Name: RMC-4998
Chemical Name: RMC-4998
CAS Number: 2642037-07-6
Molecular Formula: C₅₇H₇₄N₈O₇
Molecular Weight: 983.25
Catalog: Signaling Pathways GPCR/G Protein Ras
Create Date: 2023-09-30 09:27:09
Modify Date: 2024-01-09 13:05:10
RMC-4998 is a molecular glue compound with good antitumor activity. RMC-4998 is able to form a ternary complex with CYPA and an activated KRAS G12C mutant. Furthermore, CYPA binding to KRAS G12C blocks the interaction between activated KRAS mutants and downstream effector proteins, thereby inhibiting signaling that promotes cell proliferation[1].

Name	RMC-4998

Description	RMC-4998 is a molecular glue compound with good antitumor activity. RMC-4998 is able to form a ternary complex with CYPA and an activated KRAS G12C mutant. Furthermore, CYPA binding to KRAS G12C blocks the interaction between activated KRAS mutants and downstream effector proteins, thereby inhibiting signaling that promotes cell proliferation[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Ras
References	[1]. Christopher J Schulze, et al. Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS. Science. 2023 Aug 18;381(6659):794-799.

Molecular Formula	C₅₇H₇₄N₈O₇
Molecular Weight	983.25