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2847881-81-4

2847881-81-4 structure

2847881-81-4 structure

Name: TH-Z827
Chemical Name: TH-Z827
CAS Number: 2847881-81-4
Molecular Formula: C₃₀H₃₈N₆O
Molecular Weight: 498.66
Catalog: Signaling Pathways GPCR/G Protein Ras
Create Date: 2023-09-20 11:36:15
Modify Date: 2024-01-17 11:33:45
TH-Z827 is a mutant selective KRAS(G12D) inhibitor with an IC50 of 2.4 μM. TH-Z827 does not bind KRAS(WT) or KRAS(G12C). TH-Z827 blocked the KRAS(G12D)-CRAF interaction with an IC50 value of 42 μM[1].

Name	TH-Z827

Description	TH-Z827 is a mutant selective KRAS(G12D) inhibitor with an IC50 of 2.4 μM. TH-Z827 does not bind KRAS(WT) or KRAS(G12C). TH-Z827 blocked the KRAS(G12D)-CRAF interaction with an IC50 value of 42 μM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Ras
Target	KRAS(G12D):2.4 μM (IC50)
References	[1]. Zhongwei Mao, et al. KRAS(G12D) can be targeted by potent inhibitors via formation of salt bridge. Cell Discov. 2022 Jan 25;8(1):5.

Molecular Formula	C₃₀H₃₈N₆O
Molecular Weight	498.66

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