2649170-16-9

2649170-16-9 structure

Name: TLR7/8 agonist 8
Chemical Name: TLR7/8 agonist 8
CAS Number: 2649170-16-9
Molecular Formula: C₂₄H₃₀N₆O
Molecular Weight: 418.53
Catalog: Signaling Pathways Immunology/Inflammation Toll-like Receptor (TLR)
Create Date: 2023-11-17 16:18:44
Modify Date: 2025-08-25 11:43:36
TLR7/8 agonist 8 (compound 24m) is a potent toll-like receptor 7/8 (TLR7/8) dual agonist, with EC50s of 27 and 12 nM for hTLR7 and hTLR8, respectively. TLR7/8 agonist 8 can improve the antitumor activity of PD-1/PD-L1 blockade[1].

Name	TLR7/8 agonist 8

Description	TLR7/8 agonist 8 (compound 24m) is a potent toll-like receptor 7/8 (TLR7/8) dual agonist, with EC50s of 27 and 12 nM for hTLR7 and hTLR8, respectively. TLR7/8 agonist 8 can improve the antitumor activity of PD-1/PD-L1 blockade[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR) Research Areas >> Cancer
Target	TLR7:27 nM (EC50) TLR8:12 nM (EC50)
References	[1]. Wang Z, et, al. Structure-Based Design of Highly Potent Toll-like Receptor 7/8 Dual Agonists for Cancer Immunotherapy. J Med Chem. 2021 Jun 10;64(11):7507-7532.

Molecular Formula	C₂₄H₃₀N₆O
Molecular Weight	418.53