2478592-86-6

2478592-86-6 structure

Name: TNIK&MAP4K4-IN-1
Chemical Name: TNIK&MAP4K4-IN-1
CAS Number: 2478592-86-6
Molecular Formula: C₂₅H₂₃FN₄O₃
Molecular Weight: 446.47
Catalog: Signaling Pathways MAPK/ERK Pathway MAP4K
Create Date: 2023-10-19 10:47:59
Modify Date: 2024-01-02 23:20:36
TNIK&MAP4K4-IN-1 (compound A-39) is a dual inhibitor of TNIK and MAP4K4/HGK with IC50s of 1.29 nM and <10 nM，respectively，in human hepaticstellate cell LX-2. TNIK&MAP4K4-IN-1 can be used for cancer and fibrosis inhibition[1].

Name	TNIK&MAP4K4-IN-1

Description	TNIK&MAP4K4-IN-1 (compound A-39) is a dual inhibitor of TNIK and MAP4K4/HGK with IC50s of 1.29 nM and <10 nM，respectively，in human hepaticstellate cell LX-2. TNIK&MAP4K4-IN-1 can be used for cancer and fibrosis inhibition[1].
Related Catalog	Signaling Pathways >> MAPK/ERK Pathway >> MAP4K Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	IC50: 1.29 nM (TNIK), <10 nM (MAP4K4/HGK)[1]
References	[1]. Aliper A, et al. TNIK and/or MAP4K4 kinase inhibitors and therapeutic uses thereof in treatment of cancer and fibrosis. World Intellectual Property Organization, WO2020170203 A1 2020-08-27.

Molecular Formula	C₂₅H₂₃FN₄O₃
Molecular Weight	446.47