846539-62-6

846539-62-6 structure

Name: α-Conotoxin BuIA
Chemical Name: α-Conotoxin BuIA
CAS Number: 846539-62-6
Molecular Formula: C₅₄H₈₂N₁₄O₁₆S₄
Molecular Weight: 1311.57
Catalog: Signaling Pathways Membrane Transporter/Ion Channel nAChR
Create Date: 2023-11-17 18:52:37
Modify Date: 2024-01-08 10:57:07
α-Conotoxin BuIA is a paralytic peptide neurotoxin and a competitive nAChR antagonist, with IC50s of 0.258 nM (α6/α3β2), 1.54 nM (α6/α3β4), 5.72 nM (α3β2), respectively. α-Conotoxin BuIA can be used to distinguish nAChRs containing β2- and β4-subunit, respectively. α-Conotoxin BuIA distinguishes among αxβ2 nAChRs with a rank order potency of α6>α3>α2>α4[1].

Name	α-Conotoxin BuIA

Description	α-Conotoxin BuIA is a paralytic peptide neurotoxin and a competitive nAChR antagonist, with IC50s of 0.258 nM (α6/α3β2), 1.54 nM (α6/α3β4), 5.72 nM (α3β2), respectively. α-Conotoxin BuIA can be used to distinguish nAChRs containing β2- and β4-subunit, respectively. α-Conotoxin BuIA distinguishes among αxβ2 nAChRs with a rank order potency of α6>α3>α2>α4[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease
Target	IC50: 0.258 nM (α6/α3β2), 1.54 nM (α6/α3β4), 5.72 nM (α3β2)[1]
References	[1]. Azam L, et al. Alpha-conotoxin BuIA, a novel peptide from Conus bullatus, distinguishes among neuronal nicotinic acetylcholine receptors. J Biol Chem. 2005 Jan 7;280(1):80-7.

Molecular Formula	C₅₄H₈₂N₁₄O₁₆S₄
Molecular Weight	1311.57