866876-88-2

866876-88-2 structure

Name: α-Conotoxin PeIA
Chemical Name: α-Conotoxin PeIA
CAS Number: 866876-88-2
Molecular Formula: C₆₅H₉₈N₂₂O₂₁S₄
Molecular Weight: 1651.87
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Calcium Channel
Create Date: 2023-10-29 17:33:29
Modify Date: 2024-01-14 18:41:23
α-Conotoxin PeIA is an analgesic α-conotoxin.α-Conotoxin PeIA inhibits the α6β4, α9α10 and α3β2 nAChR.α-Conotoxin PeIA is also a potent inhibitor of N-type calcium channel via GABAB receptor activation[1][2][3].

Name	α-Conotoxin PeIA

Description	α-Conotoxin PeIA is an analgesic α-conotoxin.α-Conotoxin PeIA inhibits the α6β4, α9α10 and α3β2 nAChR.α-Conotoxin PeIA is also a potent inhibitor of N-type calcium channel via GABAB receptor activation[1][2][3].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
References	[1]. Daly NL, et al. Structure and activity of alpha-conotoxin PeIA at nicotinic acetylcholine receptor subtypes and GABA(B) receptor-coupled N-type calcium channels. J Biol Chem. 2011 Mar 25;286(12):10233-7. [2]. Hone AJ, et al. Molecular determinants of α-conotoxin potency for inhibition of human and rat α6β4 nicotinic acetylcholine receptors. J Biol Chem. 2018 Nov 16;293(46):17838-17852. [3]. Bony AR, et al. Analgesic α-conotoxins modulate native and recombinant GIRK1/2 channels via activation of GABAB receptors and reduce neuroexcitability. Br J Pharmacol. 2022 Jan;179(1):179-198.

Molecular Formula	C₆₅H₉₈N₂₂O₂₁S₄
Molecular Weight	1651.87