132996-61-3

132996-61-3 structure

Name: Osteogenic Growth Peptide
Chemical Name: D-Alanyl-L-leucyl-L-lysyl-L-arginyl-L-glutaminylglycyl-L-arginyl-L-allothreonyl-L-leucyl-D-tyrosylglycyl-N-benzylglycylglycylglycinamide
CAS Number: 132996-61-3
Molecular Formula: C₆₈H₁₁₀N₂₂O₁₈
Molecular Weight: 1523.74
Catalog: Biochemical Peptide
Create Date: 2016-07-17 08:13:25
Modify Date: 2024-01-04 15:06:57
Osteogenic Growth Peptide, OGP is a short, naturally occurring 14-mer growth factor peptide found in serum at μM concentrations.

Name	D-Alanyl-L-leucyl-L-lysyl-L-arginyl-L-glutaminylglycyl-L-arginyl-L-allothreonyl-L-leucyl-D-tyrosylglycyl-N-benzylglycylglycylglycinamide
Synonyms	Osteogenic Growth Peptide, OGP

Description	Osteogenic Growth Peptide, OGP is a short, naturally occurring 14-mer growth factor peptide found in serum at μM concentrations.
Related Catalog	Signaling Pathways >> Others >> Others Peptides Research Areas >> Others
In Vitro	Osteogenic Growth Peptide (OGP) regulates proliferation, differentiation, and matrix mineralization in osteoblast lineage cells. The active portion of OGP, the OGP(10-14) region, is cleaved from the peptide and binds to the OGP receptor which activates the MAP kinase, the Src, and the RhoA pathways[1]. Osteogenic Growth Peptide (OGP) is a native molecule with a primary structure identical to the C-terminus of histone H4, whose sequence contains a highly conserved 14-amino acid motif (NH2-ALKRQGRTLYGFGG-OH). This peptide is isolated from blood during osteogenic remodeling of post-ablation of marrow regeneration. The osteogenic growth peptide (OGP) and its C-terminal pentapeptide OGP(10-14) have been shown to stimulate the proliferation, differentiation, alkaline phosphatase activity and matrix mineralization of osteoblastic lineage cells[2].
References	[1]. Moore NM, et al. The use of immobilized osteogenic growth peptide on gradient substrates synthesized via clickchemistry to enhance MC3T3-E1 osteoblast proliferation. Biomaterials. 2010 Mar;31(7):1604-11. [2]. Pigossi SC, et al. Role of Osteogenic Growth Peptide (OGP) and OGP(10-14) in Bone Regeneration: A Review. Int J Mol Sci. 2016 Nov 22;17(11). pii: E1885.