- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: D-kynurenine
- Price:
- Purity: 98.0%
- Stocking Period: 10 Day
- Contact: Yang
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: D-kynurenine
- Price: ￥578.0/25mg ￥1968.0/100mg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: D-Kynurenine
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: D-Kynurenine
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
13441-51-5
13441-51-5 structure
- Name: D-kynurenine
- Chemical Name: D-kynurenine
- CAS Number: 13441-51-5
- Molecular Formula: C10H12N2O3
- Molecular Weight: 208.214
- Catalog: Biochemical Common amino acids and protein drugs
- Create Date: 2018-08-07 17:58:07
- Modify Date: 2024-01-03 18:24:33
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D-kynurenine, a metabolite of D-tryptophan, can serve as the bioprecursor of kynurenic acid (KYNA) and 3-hydroxykynurenine. D-Kynurenine is an agonist for G protein-coupled receptor, GPR109B. D-Kynurenine is a substrate in a fluorometric assay of D-amino acid oxidase. D-kynurenine promotes epithelial-to-mesenchymal transition via activating aryl hydrocarbon receptor (AHR)[1][2][3][4].
| Name | D-kynurenine |
|---|---|
| Synonyms |
D-kynurenine
|A-Anthraniloyl-D-alanine (2R)-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid MFCD00133224 Benzenebutanoic acid, α,2-diamino-γ-oxo-, (αR)- β-Anthraniloyl-D-alanine D-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid (R)-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid |
| Description | D-kynurenine, a metabolite of D-tryptophan, can serve as the bioprecursor of kynurenic acid (KYNA) and 3-hydroxykynurenine. D-Kynurenine is an agonist for G protein-coupled receptor, GPR109B. D-Kynurenine is a substrate in a fluorometric assay of D-amino acid oxidase. D-kynurenine promotes epithelial-to-mesenchymal transition via activating aryl hydrocarbon receptor (AHR)[1][2][3][4]. |
|---|---|
| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| In Vitro | D-kynurenine (10, 40, 60, and 100 µM) positively regulates the metastasis of 95D cells, a lung cancer cell line, which is reduced upon siRNAAhr treatment. Significant enhancement VIM expression was detected in the presence of D-kynurenine (10 and 40 µM). 10 µM D-kynurenine markedly attenuates E-cadherin level. 10 µM D-kynurenine-mediated changes of VIM and E-cadherin are substantially attenuated on siRNAAhr treatment as well. The evidences-10/40 µM D-kynurenine-induced up-regulation of CYP1A1, 10 µM D-kynurenine-induced increase of nuclear transfer of Ahr, and 10/40/60/100 µM D-kynurenine-induced enhancement of DER-luciferase activity-indicated that D-kynurenine Is capable of activating Ahr in fact[4]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 466.6±45.0 °C at 760 mmHg |
| Molecular Formula | C10H12N2O3 |
| Molecular Weight | 208.214 |
| Flash Point | 236.0±28.7 °C |
| Exact Mass | 208.084793 |
| PSA | 106.41000 |
| LogP | 1.09 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.626 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2922509090 |
|
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13441-51-5 |
| Literature: WO2010/148191 A2, ; Page/Page column 45-49; 61 ; |
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13441-51-5 |
| Literature: Biochemistry, , vol. 49, # 12 p. 2647 - 2656 |
| HS Code | 2922509090 |
|---|---|
| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |