1080623-12-6
1080623-12-6 structure
- Name: VUF-10497
- Chemical Name: VUF-10497
- CAS Number: 1080623-12-6
- Molecular Formula: C18H20ClN5S
- Molecular Weight: 373.9
- Catalog: Signaling Pathways GPCR/G Protein Histamine Receptor
- Create Date: 2024-04-07 05:51:04
- Modify Date: 2024-04-07 05:51:04
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VUF-10497 is a histamine H4 receptor inverse agonist (pKi = 7.57). VUF-10497 was found to possess anti-inflammatory properties in vivo in the rat. VUF-10497 also possesses a considerable affinity for the human histamine H1 receptor.
| Name | VUF-10497 |
|---|
| Description | VUF-10497 is a histamine H4 receptor inverse agonist (pKi = 7.57). VUF-10497 was found to possess anti-inflammatory properties in vivo in the rat. VUF-10497 also possesses a considerable affinity for the human histamine H1 receptor. |
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| References | 1. Smits RA, de Esch IJ, Zuiderveld OP, Broeker J, Sansuk K, Guaita E, Coruzzi G, Adami M, Haaksma E, Leurs R. Discovery of quinazolines as histamine H4 receptor inverse agonists using a scaffold hopping approach. J Med Chem. 2008 Dec 25;51(24):7855-65. doi: 10.1021/jm800876b. PubMed PMID: 19053770. |
| Molecular Formula | C18H20ClN5S |
|---|---|
| Molecular Weight | 373.9 |