1801243-39-9
1801243-39-9 structure
- Name: KLS-13019
- Chemical Name: KLS-13019
- CAS Number: 1801243-39-9
- Molecular Formula: C22H29NO3
- Molecular Weight: 355.47
- Create Date: 2024-03-13 17:46:11
- Modify Date: 2025-08-24 23:06:10
-
KLS-13019 is a Cannabidiol-Derived Neuroprotective Agent with Improved Potency, Safety, and Permeability. (EC50=40nM; T1=7500). KLS-13019 was 50-fold more potent and >400-fold safer than cannabidiol and exhibited an in vitro profile consistent with improved oral bioavailability. KLS-13019 was only toxic at 300 μM giving it a therapeutic index of 7500.
| Name | KLS-13019 |
|---|
| Description | KLS-13019 is a Cannabidiol-Derived Neuroprotective Agent with Improved Potency, Safety, and Permeability. (EC50=40nM; T1=7500). KLS-13019 was 50-fold more potent and >400-fold safer than cannabidiol and exhibited an in vitro profile consistent with improved oral bioavailability. KLS-13019 was only toxic at 300 μM giving it a therapeutic index of 7500. |
|---|---|
| References | 1. Discovery of KLS-13019, a Cannabidiol-Derived Neuroprotective Agent, with Improved Potency, Safety, and Permeability. William A. Kinney, Mark E. McDonnell, Hua Marlon Zhong, Chaomin Liu, Lanyi Yang, Wei Ling, Tao Qian, Yu Chen, Zhijie Cai, Dean Petkanas, and Douglas E. Brenneman。 Publication Date (Web): February 10, 2016 (Letter)。 DOI: 10.1021/acsmedchemlett.6b00009 |
| Molecular Formula | C22H29NO3 |
|---|---|
| Molecular Weight | 355.47 |